The state’s Butantan Institute has capacity for 1 million doses of CoronaVac per day, he said. Sao Paulo plans to kick off vaccination efforts on Jan. 25, despite President Jair Bolsonaro’s repeated objections to the Sinovac shot. Meanwhile, the country’s health minister Thursday pledged to vaccinate Brazil’s entire population against COVID-19 in 2021. But those proteins are almost nothing alike, an expert in maternal and neonatal immunity at Duke University told the Times.
Pfizer, meanwhile, pointed to a recent study showing its vaccine didn’t appear to raise the risk of pregnancy-related problems. NovartisandIncyte’sJAK1/JAK 2 inhibitorJakafi, also known asruxolitinib,missed the mark in a phase 3 study to see whether it could help patients aged 12 years and older with COVID-19-related cytokine storm. Temple University Hospital in Philadelphia expects to get 2,000 doses this week, with the goal to ultimately immunize between 7,000 and 8,000 patient-facing employees across its sites. Delaware on Monday received its first 9,000-dose shipment and will start giving the shot to frontline workers Tuesday. Meanwhile, the Cooper health system in New Jersey also plans to kick off vaccination efforts today. Once the university starts vaccinating people, it will send the CDC and the California Department of Public Health an accountability log of the number of doses administered each day.
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Meanwhile, the school is working with ethicists, doctors and health equity experts to determine who should receive the first doses. Long Island-basedCodagenixgot the OK to start a phase 1 trial of its nose drop COVID-19 vaccine in the U.K. Speaking ofPfizer,why hasn’t CEO Albert Bourla taken the drugmaker’s vaccine yet? COVAX aims to start deliveries in the first quarter of 2021, assuming the shots are approved. Belgium’s budget state secretary, Eva De Bleeker, tweeted—and then deleted—the prices the EU has negotiated for Pfizer and Moderna’s vaccines, The New York Times reports. Pfizer’s shot, due for a European approval decision Monday, will cost €12 ($14.70) per dose, bringing up the cost for a full two-dose course to €24 ($29.38).
- will have to wait 11 weeks before they can get their second dose ofPfizerandBioNTech’svaccine, Manchester Evening News reports.
- A CSL spokeswoman told the news outlet that the first locally produced doses would be available in the second quarter of the year, subject to regulatory approval.
- The British government last month unveiled plans to delay patients’ second shots as the country prioritizes delivery of initial doses.
- Pfizer itself has cautioned against the move, warning that available data do not support a longer lag time between doses.
Vaccine rollouts in other countries are also moving more slowlythan expected, The New York Times reports. England aims to vaccinate some 13.9 million citizens from its four most vulnerable groups by February, Prime Minister Boris Johnson said, but as of Dec. 27, fewer than 800,000 people in the country had received the shot. The variant, which has cropped up in South Africa and Brazil, seems to partially escape prior immunity, which could make recovered patients’ own antibodies and currently approved antibody therapies less effective, Gottlieb warned. Exports to theWHO’sCovax distribution initiative won’t start until March or April, though SII is working to sign a larger agreement with Covax for 300 million to 400 million doses, he said. SII has so far pledged 200 million doses to the distribution effort, split between AZ andNovavax’sshots. approval within weeks, local scientists and government officials told The Telegraph.
Bahrain,located in the Persian Gulf, became the second nation after the U.K.to approvePfizerandBioNTech’smRNA vaccine, a state-run news agency announced Friday. Both Pfizer and Bahrain are keeping details on the volume and timing of the country’s vaccine order close to the vest. NeuroRxandRelief Therapeuticshit the enrollment target for a phase 2b/3 trial of their drug RLF-100, also known as aviptadil, in patients with COVID-19 respiratory failure. The CDMO was one of the original partners in Oxford’s consortium to manufacture the shot, Halix added. Revving up for a mass vaccination program, Indonesia on Sundayreceived its first, 1.2 million-dose vaccine shipment from China’s Sinovac, the country’s president said.
Moderna’s shot will cost $18 per dose, or $36 for a full course, according to the leaked price list. Walgreens Boots AllianceandCVS Healthare spearheading a program, in partnership with the federal government, to vaccinate roughly 7 million people in more than 70,000 long-term care facilities across the U.S. While some residents received shots last week, the partners’ full rollout kicked off Monday, Reuters reports. government has said some 530,000 AZ doses should be available in the country Monday, local outlet Channel 4 News reported. South Korea in December inked a deal for 20 million AZ doses, and initial shipments could arrive as early as this month. The country also has deals withPfizer, ModernaandJohnson & Johnson,with plans to start vaccinations in February. Wisconsin’s Steven Brandenburg, arrested last week, could face charges for the move that sent enough vaccine product for 500 people down the drain.
The government plans to grab another 1.8 million doses in January and is awaiting shipments of raw materials to crank out 15 million doses this month, followed by materials for 30 million more doses in January, he added. Earlier this month, The Wall Street Journal reported that North Korean hackers had targeted AZ,Johnson & JohnsonandNovavax,as well as three South Korean drugmakers working on COVID-19 meds. Canada Wednesday became the third country to authorizePfizerandBioNTech’smRNA vaccine, paving the way for a shot rollout as early as next week. Pfizer will supply Canada with up to 76 million doses of its vaccine, a spokeswoman for the drugmaker’s Canadian unit said. On Monday, the country said it had secured early delivery of 249,000 initial doses in anticipation of vaccination efforts next week. Brazil’s Sao Paulo state on Thursday started producing Sinovac’s COVID-19 vaccine hopeful, Governor João Doria said.
Britain has purchased 30 million doses of the vaccine, developed by J&J’s Janssen unit, with the option to purchase another 22 million doses. Meanwhile, U.K. Vaccine Taskforce adviserSir John Bellsaid he was hopeful J&J supplies could reach the country in time for British vaccination rates to pick up by mid-February. South Africa’s Aspen Pharmacarecould start producing doses ofJohnson & Johnson’svaccine in late March or early April, if approvals are in place, Stavros Nicolaou, group senior executive for strategic trade at Aspen, told Reuters.
The deal brings the government’s total potential order to over 1.5 million doses. InitialJohnson & Johnson vaccine shipments could arrive in Europe by April 1, a European Union official told Reuters. The European Medicines Agency has been conducting a rolling review of J&J’s shot since the start of December. Speaking ofAstraZeneca,the Serum Institute of India expects WHO to issue an emergency nod for the British drugmaker’s shot “in the next week or two,” SII chiefAdar Poonawallasaid at the Reuters Next conference. SII hopes to start supplying shots to the agency’s equitable vaccine distribution effort,Covax,by the end of January, he said. Kessler will work to speed deliveries of vaccines throughout the country and is also expected to kick off a major antiviral development program, transition officials told NYT. Aviptadil ihas a demonstrated 20 year history of safety in phase 2 trials for Sarcoid, Pulmonary Fibrosis, Bronchospasm, and a phase I trial in ARDS.
All shots produced by Aspen will be exported and folded into J&J’s global supply, Nicolaou said. South Africa is in “advanced” talks with Johnson & Johnson to lock down vaccine supplies, the country’s health ministry said Thursday. Local manufacturer Aspen Pharmacare aims to kick off production of J&J’s shot in late March or early April, but those Aspen doses are earmarked for export. Meanwhile, it’s looking to boost supply capacity by introducing a new six-dose vial, alongside plans to establish new sites, suppliers and CMO pacts. Select Publix pharmacies in Florida will start deployingCOVID-19 vaccines, Gov. Ron DeSantis said—and all available appointments have already been booked, local outlet ClickOrlando reports. Each site plans to vaccinate around 120 people per day, the supermarket chain said.
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SanofiandGlaxoSmithKlineplan to announce the price of their COVID-19 vaccine candidate upon the release of phase 1/2 trial results, expected before the end of the month, Thomas Triomphe, vaccines chief at Sanofi, said Thursday. An editorial in The New England Journal of Medicine is challenging a large, WHO-run trial that foundGilead’santiviralVeklury,also known asremdesivir,did little to improve COVID-19 survival. WHO’s trial took place across 30 countries, fueling inconsistencies in the data collected. The pandemic has at times created huge surges in demand for medical supplies such as personal protective equipment and testing supplies.