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Most, but not all, of these patients had preexisting cardiovascular risk factors. Analysis of the safety database from controlled clinical trials showed no apparent difference in adverse reactions in patients taking VIAGRA with and without anti-hypertensive medication. This analysis was performed retrospectively, and was not powered to detect any pre-specified difference in adverse reactions. When VIAGRA is co-administered with an alpha-blocker, patients should be stable on alpha-blocker therapy prior to initiating VIAGRA treatment and VIAGRA should be initiated at 25 mg . VIAGRA , an oral therapy for erectile dysfunction, is the citrate salt of sildenafil, a selective inhibitor of cyclic guanosine monophosphate -specific phosphodiesterase type 5 .

  • Most studies assessed the efficacy of VIAGRA approximately 60 minutes post dose.
  • When VIAGRA is co-administered with an alpha-blocker, patients should be stable on alpha-blocker therapy prior to initiating VIAGRA treatment and VIAGRA should be initiated at the lowest dose .
  • VIAGRA has systemic vasodilatory properties that resulted in transient decreases in supine blood pressure in healthy volunteers (mean maximum decrease of 8.4/5.5 mmHg), .
  • Mean resting values for right atrial pressure, pulmonary artery pressure, pulmonary artery occluded pressure and cardiac output decreased by 28%, 28%, 20% and 7% respectively.
  • The erectile response, as assessed by RigiScan®, generally increased with increasing sildenafil dose and plasma concentration.

Viagra has about 49 percent of the market for sexual dysfunction treatments, followed by Cialis, which holds 39.7 percent, and Levitra, with 8.6 percent, according to IMS Health. Pfizer said it conducted a survey in 2011 in which it evaluated 22 Web sites appearing in the top search results for the phrase “buy Viagra.” Chemical analyses found that about 80 percent of the pills were counterfeit. Since Viagra arrived on the market in 1998, Pfizer has sought to minimize the stigma around male impotence — rebranded as erectile dysfunction, or E.D. — by enlisting celebrity endorsers like the former Republican presidential candidate Bob Dole and encouraging men to have the “Viagra talk” with their doctors. Patients should be stable on alpha-blocker therapy prior to initiating VIAGRA treatment.

What Should I Tell My Healthcare Provider Before Taking Viagra?

Aside from ingesting harmful ingredients, the amount of active ingredient can dramatically vary from one batch to another. The pills in question were manufactured in China and then shipped to Hong Kong. From Hong Kong, the pills were sent through the free trade zone in Dubai and then delivered to the U.K. In addition, taking Viagra with too much alcohol can lead to orthostatic hypotension, which is a drop in blood pressure when you go from a sitting or lying down position to standing. Symptoms include a headache, dizziness, or fainting when standing. Peak plasma concentrations of Viagra are reached within 30 to 120 minutes of a single dose. The onset of effect takes about 30 to 60 minutes alongside sexual stimulation.

This medication is taken with or without food about one to two hours before sex. It can be taken in a small dose daily or in a larger dose as needed. This medication is most effective when taken on an empty stomach one hour before sex.

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Do not give this medicine to anyone under 18 years old without medical advice. It is not known whether sildenafil passes into breast milk or if it could harm a nursing baby.

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It’s effective for four to five hours or more if you have mild to moderate erectile dysfunction. Your dosage will depend on your medical condition, your overall health, and other factors. Grapefruit may interact with sildenafil and lead to unwanted side effects. Do not give this medication to anyone under 18 years old without medical advice. if you have been told you should not have sexual intercourse for health reasons.

The 3 dosages of VIAGRA—25 mg, 50 mg, and 100 mg—are the only dosages of sildenafil citrate that are FDA approved for the treatment of ED. VIAGRA® is indicated for the treatment of erectile dysfunction . Viagra is one of Pfizer’s top drugs, with $2 billion in worldwide revenue last year. Dosage variability and incorrect labeling may also lead to accidental overdose or the risk of an adverse effects associated with a drug-to-drug interaction.

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Never take other ED medications at the same time as taking Viagra. Always buy your ED medications from a reputable supplier as there are a lot of counterfeit products on the market. However, it may be taken anywhere from 30 minutes to four hours before sexual activity. Viagra belongs to the class of medicines known as PDE-5 inhibitors. Sildenafil blocks the action of an enzyme known as cGMP-specific phosphodiesterase type-5 (PDE-5). Grapefruit and grapefruit juice may interact with sildenafil and lead to unwanted side effects.

What Happens If I Overdose?